The oldest document that mentions the settlement of Sintandrei dates from XIII and XIV centuries, the document being from 1291, where the mentioning speak about a settlement called "Santus Andrea". Archaeological evidences shows that the territory of Sintandrei was inhabited since ancient times. Traces of old settlements are fragments of painted pottery from Neolithic and Bronze Age traces of a cemetery, tools and weapons, the oldest dating from the Neolithic and Bronze Age. Besides the Bronze Age, which is well represented by many artifacts the Iron Age is also well represented.
In 1311 Sintandrei village - then called "Villa Sant Andreae" - appears as the property of Count Andrei of Borș. In 1332 the village is mentioned in the papal taxes registries as "Sancto Andreas" and then "Zenthandres". After two years the settlement divided in two parts, one going into the possession of the Oradea Bishop. In 1907 the name changes from "Szentandres" in "Bihar", and in 1913 is used as "Sîntandrei Bihor".
Sîntandrei is located in the west of the country (North-West Development Region), in the western part of Bihor County. In Oradea Metropolitan Area Sîntandrei has a relatively central location being bordered to the east by Oradea, the south Nojorid, west Girişu de Criş and to the north Borş.
Sîntandrei administratively is composed by two villages: Palota and Sîntandrei. The last one is also the administrative seat of the authority.
Sîntandrei can be reached both by road and railway. The main roads that reaches Sîntandrei is the county road DJ797 that also facilitates the access to other local authorities such as: Tărian, Girişu de Criş, Toboliu, Sânnicolau Român, Inand.
In Sîntandrei there is one railway station belonging to CFR, the settlement being crossed by the main Railway 300 that passes through the following cities : Bucureşti - Braşov - Sighişoara - Teiuş - Războieni - Cluj Napoca – Oradea.
Air access can be achieved through the Oradea International Airport, located at a distance of about 7 km from the village of Sintandrei.
Sîntandrei covers an area of 28.01 km2, occupying a share of 3.7% of the total area of Oradea Metropolitan Area. It is the member of Oradea Metropolitan Area with the smallest land mass.
Sîntandrei is one of the smallest villages in Bihor County, accounting for only 0.4% of the total land of the county. Only Pocola local authority has an area smaller than that of Sîntandrei (24.35 km2).
Sîntandrei is located in the Miersig Plain, piedmont plain located at the contact point with Hills and Meadows of the Black Crişu. Thus Miersig Plain is one of the plain within the western plains with a higher elevation along with the plains of Carei, Ierului, Miersig, Cermei, Aradului, Vingăi şi Gătaiei. The elevated plains formed through a process of accumulation and erosion due to its vicinity to the Crișul Repede river. Although arranged in terraces the overall inclination has a peak of 200 m, near the hills, to 110 m towards the lower plains.
Climatic conditions in Sîntandrei are under the influence of the western air circulations that cary humid oceanic air. Average annual air temperature has ranged between 10 ° -11 ° C, values specific for plain regions. Average annual rainfall values are between 600-700 mm/year. Most frequent winds are the southern ones followed by the west and those from the northern part.
About 75% of the total area of Sîntandrei is destined for agricultural purposes, either for crops or pasture land. The forest area at the local level is quite small the community being in a plan region.
Sîntandrei is crossed by Crişul Repede River, the area having allot for fishing grounds.
In terms of natural reservations Sîntandrei has a Natura 2000 site ROSCI0104 Lower Meadow of Crişului Repede River. This stretches also into other neighboring communities: Borş, Girişu de Criş and Oradea. The site is acknowledged by the population of Zăvoaie with white Salix and white Populus, being covered of rivers and lakes 36% arable land 26%, grassland 21%, swamps 15% peats and another 2% of other arable lands. Amongst the most important species found in the lower meadow of the Crișu river are: Buhaiul de baltă, Porcuşorul de şes, Boarcă, Dunariţă, Zvârlugă, Răspăr, Pietrar, Fusar mic, Petroc, etc.